|
 |
Centres Germany |
| Prof. Georg Schett | |
| Personal | Georg Schett is Director of the Department of Internal Medicine III and Institute for Clinical Immunology at the University of Erlangen-Nuremberg, Germany. Within his department, 10 to 15 fellows are trained per year in the areas of basic immunology and immunology related to rheumatic diseases. |
| Interests | Professor Schett’s special clinical interest is the diagnosis and treatment of rheumatic diseases, with particular emphasis on rheumatoid arthritis (RA), lupus erythematosus, and systemic vasculitis syndromes. His clinical practice is focused on RA, spondylarthritis and connective tissue diseases. The focus of research in his department is the pathogenesis of RA and lupus and the development of disease-modifying compounds. |
| Research Projects |
1. Program on cell death and its relation to the pathogenesis of systemic lupus erythematosus. This research group is headed by Professor Martin Herrmann 2. Investigations on the pathogenesis of cartilage and bone destruction in inflammatory diseases. This project is handled by Dr Jochen Zwerina 3. Practical exercises in treating patients with new biologics, including research on the development of anti-TNF-alpha antibodies in patients receiving anti-TNF medication. This project is led by Professor Georg Schett |
| Recent Publications |
Urbonaviciute, V., B.G. Fürnrohr, S. Meister, L. Munoz, P. Heyder, F.De Marchis, ME. Bianchi, C. Kirschning, H. Wagner, AA. Manfredi, JR. Kalden, G. Schett, P. Rovere-Querini, M.Herrmann and R.E.Voll. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med. 2008; 205(13):3007-18. McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007;7:429-442. Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G. Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007;13:156-163. Zwerina J, Redlich K, Polzer K, Joosten L, Krönke G, Distler J, Hess A, Pundt N, Pap T, Hoffmann O, Gasser J, Scheinecker C, Smolen JS, van den Berg W, Schett G. TNF-induced structural joint damage is mediated by IL-1. Proc Natl Acad Sci U S A. 2007;104:11742-11747. Wada T, Nakashima T, Oliveira-dos-Santos AJ, Gasser J, Hara H, Schett G, Penninger JM. The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 2005;11:394-39
|
| close window | print page |