Centres Germany    
  Prof. Gerd-Rüdiger Burmester
Personal Professors Burmester and Hiepe are based at the Charite-Universitätsmedizin Berlin, Med Klinik m.S. Rheumatologie und klin Immunologie (headed by Professor Burmester). The department trains 8 fellows per year in the area of rheumatology.
Interests Professors Hiepe’s and Burmester’s clinical practice focuses on rheumatoid arthritis, connective tissue disease, Lyme arthritis, and systemic vasculitides. Their research activities include genomics in inflammatory rheumatic diseases (within the National Genome Research Network), new therapeutic approaches for inflammatory and auto-immune diseases, role of memory plasma cells in autoimmunity and allergy, pathogenic and diagnostic relevance of autoantibodies, tissue engineering, regulatory T-cells and autoimmunity, and animal models of autoimmunity. This research is carried out in close collaboration with the German Arthritis Research Center (DRFZ) in Berlin.
Research
Projects 		1. Development of new autoantibody tests for rheumatoid arthritis (RA)
2. Protective versus autoreactive plasma cell memory
3. Regulatory T-cells
4. Glucocorticoid receptors and inflammation
5. Gene expression in RA
6. Gene expression in SLE
7. New autoantibodies in systemic sclerosis
8. Proteasomes and anti-proteasome antibodies The department provides lectures and practical exercises in rheumatology and clinical immunology.
See rheumatologie.charite.de for more information.
Recent
Publications

Brychcy M, Kuckelkorn U, Hausdorf G, Egerer K, Kloetzel PM, Burmester GR, and Feist E. Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28. Arthritis Rheum. 2006;54:2175-2183.

Hoyer BF, Moser K, Hauser AE, Peddinghaus A, Voigt C, Eilat D, Radbruch A, Hiepe F, and Manz RA. Short-lived Plasmablasts and Long-lived Plasma Cells Contribute to Chronic Humoral Autoimmunity in NZB/W Mice. J Exp Med. 2004;199:1577-1584.

Huehn J, Siegmund K, Lehmann JC, Siewert C, Haubold U, Feuerer M, Debes GF, Lauber J, Frey O, Przybylski GK, Niesner U, de la Rosa M, Schmidt CA, Brauer R, Buer J, Scheffold A, and Hamann A. Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med. 2004;199:303-313.

Pandiyan P, Gartner D, Soezeri O, Radbruch A, Schulze-Osthoff K, and Brunner-Weinzierl MC. CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function. J Exp Med. 2004;199:831-842.

Skriner K, Adolph K, Jungblut PR, and Burmester GR. Association of citrullinated proteins with synovial exosomes. Arthritis Rheum. 2006;54:3809-3814.
   
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