Professor Pavelka’s special clinical interests are osteoarthritis, osteoporosis, pharmacology, and biologic therapies. He has a large clinic for the treatment of all inflammatory diseases.
The focus of the research within his department are both in basic and clinical science. These are connective tissue diseases, myositis, registries or rheumatoid arthritis and spondylarthritides, immunology, clinical pharmacology, and genes susceptible to rheumatoid arthritis (RA), outcome measures in rheumatology, imaging and glucocorticoid-induced osteoporosis. The research is focused on the molecular and cellular pathways involved in the pathogenesis of several autoimmune diseases. Selected molecules, namely adipocytokines and S100 proteins, are studying for their function(s) in the joint destruction and immune response.
Further information is available at: www.revma.cz/crs/index.htm

Scientist:
prof. Jiří Vencovský, M.D., Ph.D.
prof. Jan Štěpán, M.D., Ph.D.
as. prof. Ladislav Šenolt, M.D., Ph.D.
as. prof. Radim Bečvář, M.D., Ph.D.

Pavelka K, Gatterova J, Olejarova M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002;162:2113-23.

Vilim V, Vytasek R, Olejarova M, … Pavelka K. Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis. Osteoarthritis Cartilage. 2001;9:612-8.

Pavelka K, Forejtova S, Pavelkova A, et al. Analysis of the reasons for DMARD therapy discontinuation in patients with rheumatoid arthritis in the Czech and Slovak republics. Clin Rheumatol. 2002;21:220-6.

Pavelka K, Gatterova J, Altman RD. Radiographic progression of knee osteoarthritis in a Czech cohort. Clin Exp Rheumatol. 2000;18:473-7.

Pavelka K, Forejtová Š, Olejárová M, et al. Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis. Osteoarthritis and Cartilage. 2004;12:277-83.

Dostál C, Pavelka K, Zvárová J, Hanzlíček P, Olejárová M. Some principles of the development of a clinical database / national register of selected inflammatory rheumatic diseases in the Czech Republic. International Journal of Medical Informatics 2006; 75: 216-223.

Šenolt L, Pavelka K, Housa D, Haluzík M. Increased adiponectin is negatively linked to the local inflammatory process in patiens with rheumatoid arthritis. Cytokine 200; 35: 247-252.

Šenolt L, Grigorian M, Lukanidin E, Michel BA, Gay RE, Gay S, Pavelka K, Neidhart M. S100A4 (Mts1): is there any relation to the pathogenesis of rheumatoid arthritis? Autoimmun. Rev 2006; 5: 129-31

Šenolt L, Housa D, Vernerová Z, Jirásek T, Svobodová R, Veigl D, Anderleová K, Müller-Ladner U, Pavelka K, Haluzík M. Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis 2007; 66: 458-463

Pavelka K, Gatterová J, Tegzová D et al. Radiographic progression of rheumatoid arthritis in patiens from the Czech National Registry receiving infliximab treatment. Clinical and Experimental Rheumatology 2007; 25:540-545

Hanová P, Pavelka K, Dostál C, Holcátová I, Pikhart H. Epidemiology of rheumatoid arthritis, juvenile diopathic arthritis and gout in two region sof the Czech Republic in a descriptive population-based survey in 2002-2003. Clinical and Experimental Rheumatology 2006; 24: 499-507.

Pavelka K, Trč T, Karpat K et al. The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knne. A randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of three-month treatment period. Arthritis Rheumatism 2007; Vol.56, 12: 4055-4064

Forejtová Š, Mann H, Štolfa J, Vedral K, Fenclová I, Némethová D, Pavelka K. Factors influencing health status and disability of patients with ankylosing spondylitis in the Czech Republic. Clin Rheumatol 2008;27:1005-1013

Růžičková Š, Šenolt L, Gatterová J, Vencovský J, Pavelka K. The Lack of Correlation between the Increased Frequency of Allele IL-1RN*2 of Interleukin-1 Receptor Antagonist Gene in Czech Patients with Knee Osteoarthritis and the Markers of Cartilage Degradation. Folia Biologica (Praha) 2008;54:115-120

Pavelka K, Trč T, Karpat K et al. The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knne. A randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of three-month treatment period. Arthritis Rheumatism 2007; Vol.56, 12: 4055-4064

Hulejová H, Baresová V, Klézl Z, Polanská M, Adam M, Šenolt L. Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone. Cytokine. 2007;38:151-6.

Oslejskova L, Grigorian M, Gay S, Neidhart M, Senolt L. The metastasis associated protein S100A4: a potential novel link to inflammation and consequent aggressive behavior of rheumatoid arthritis synovial fibroblasts. Ann Rheum Dis 2008;67:1499-504

Senolt L, Grigorian M, Lukanidin E, Simmen B, Michel BA, Pavelka K, Gay RE, Gay S, Neidhart M. S100A4 is expressed at site of invasion in rheumatoid arthritis synovium and modulates production of matrix metalloproteinases. Ann Rheum Dis. 2006;65:1645-8.

Senolt L, Vencovský J, Pavelka K, Ospelt C, Gay S. Prospective new biological therapies for rheumatoid arthritis. Autoimmun Rev. 2009 Dec;9(2):102-7.

Filková M, Haluzík M, Gay S, Senolt L. The role of resistin as a regulator of inflammation: Implications for various human pathologies. Clin Immunol. 2009 Nov;133(2):157-70.

Filková M, Lisková M, Hulejová H, Haluzík M, Gatterová J, Pavelková A, Pavelka K, Gay S, Müller-Ladner U, Senolt L. Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis.Ann Rheum Dis 2009;68:295-6.

Oslejsková L, Grigorian M, Hulejová H, Vencovsky J, Pavelka K, Klingelhöfer J, Gay S, Neidhart M, Brabcová H, Suchy D, Senolt L. Metastasis-inducing S100A4 protein is associated with the disease activity of rheumatoid arthritis. Rheumatology (Oxford). 2009 Dec;48(12):1590-4.

Filková M, Senolt L, Braun M, Hulejová H, Pavelková A, Sléglová O, Kupka K, Gatterová J, Pavelka K. Serum hyaluronic acid as a potential marker with a predictive value for further radiographic progression of hand osteoarthritis. Osteoarthritis Cartilage. 2009;17(12):1615-1619

Mann HF, Vencovsky J, Lundberg IE. Treatment Resistant Inflammatory Myopathy. Best Pract Res Clin Rheumatol 2010; in press.

Kryštůfková O, Vallerskog O, Barbasso Helmers S, Mann H, Půtová I, Běláček J, Malmstrom V, Trollmo C, Vencovský J, Lundberg IE. Increased serum levels of B-cell activating factor (BAFF) in subsets of patients with idiopathic inflammatory myopathies. Ann Rheum Dis 2009;68:836-43.

Tomasová Studýnková J, Charvát F, Jarošová K, Vencovský J. The role of MRI in the assessment of polymyositis and dermatomyositis. Rheumatology (Oxford) 2007, 46: 1174-1179. IF 2007: 4,04